...
...
Read Article
- More Betting
Panthers vs. 49ers prediction: San Francisco favored to win MNF Week 12, 2025
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Carolina Panthers vs San Francisco 49ers predictions for NFL Monday.
The San Francisco 49ers will face the Carolina Panthers in NFL Week 12 action at Levi's Stadium on Monday, beginning at 8:15PM ET.
Based on updated simulations, Dimers' advanced NFL model predicts the 49ers as the most likely winner of the Panthers vs. 49ers game.
This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.
Panthers vs. Niners prediction: Who will win and cover?
Since our Panthers-49ers predictions earlier in the week, we have simulated the result of Monday's NFL game between the Panthers and 49ers 10,000 times as part of our NFL predictions coverage.
Our famous predictive model currently gives the 49ers a 75% chance of beating the Panthers in Week 12 of the NFL season. Our predicted final score has the 49ers winning 28-21.
According to our model, the bookmakers have got it right, and the Panthers and 49ers each have a 50% chance of covering the spread, while the over/under total of 49.5 points also has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 12 straight up picks.
Panthers vs. 49ers odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Panthers | 49ers |
|---|---|---|
| Spread | +7.5 (-115) | -7.5 (-102) |
| Moneyline | +310 | -350 |
| Total | o49.5 (+100) | u49.5 (-122) |
All odds are correct at the time of publication and are subject to change.
Panthers vs. 49ers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 49ers -7.5 | -102 |
| Moneyline | Panthers | +310 |
| Total | Over 49.5 | +100 |
According to our NFL best bets, the top play to make on this game is Panthers to win.
Panthers vs. 49ers TD scorers
Who will score a touchdown in Panthers vs. 49ers?
According to our list of touchdown scorer predictions for today, Christian McCaffrey is most likely to score an anytime touchdown in Panthers vs. 49ers.
Our projections give McCaffrey a 67.4% chance of getting in for six at Levi's Stadium, while the running back is a 19.0% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
Carolina Panthers
| Player | Anytime TD Probability |
|---|---|
| Rico Dowdle (RB) | 47.4% |
| Tetairoa McMillan (WR) | 34.9% |
| Xavier Legette (WR) | 19.9% |
| Jalen Coker (WR) | 18.3% |
| Ja'Tavion Sanders (TE) | 14.0% |
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey (RB) | 67.4% |
| George Kittle (TE) | 42.0% |
| Jauan Jennings (WR) | 32.0% |
| Ricky Pearsall (WR) | 28.4% |
| Brian Robinson (RB) | 19.7% |
First touchdown scorer predictions
Carolina Panthers
| Player | First TD Probability |
|---|---|
| Rico Dowdle (RB) | 11.4% |
| Tetairoa McMillan (WR) | 7.6% |
| Xavier Legette (WR) | 3.9% |
| Jalen Coker (WR) | 3.6% |
| Ja'Tavion Sanders (TE) | 2.7% |
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey (RB) | 19.0% |
| George Kittle (TE) | 9.2% |
| Jauan Jennings (WR) | 6.5% |
| Ricky Pearsall (WR) | 5.7% |
| Brian Robinson (RB) | 3.7% |
Panthers vs 49ers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Panthers and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 12 games.
Quarterbacks
Of the starting quarterbacks, the Panthers' Bryce Young is projected for 215 passing yards, while the 49ers' Brock Purdy is expected to throw for 257 yards.
| Player | Proj. Pass Yards |
|---|---|
| Bryce Young (CAR) | 215 |
| Brock Purdy (SF) | 257 |
Panthers rushing
| Player | Proj. Rush Yards |
|---|---|
| Rico Dowdle | 77 |
| Chuba Hubbard | 19 |
| Bryce Young | 12 |
49ers rushing
| Player | Proj. Rush Yards |
|---|---|
| Christian McCaffrey | 70 |
| Brian Robinson | 30 |
| Brock Purdy | 13 |
Panthers receiving
| Player | Proj. Rec. Yards |
|---|---|
| Tetairoa McMillan | 70 |
| Jalen Coker | 35 |
| Xavier Legette | 31 |
| Ja'Tavion Sanders | 23 |
| Rico Dowdle | 20 |
49ers receiving
| Player | Proj. Rec. Yards |
|---|---|
| George Kittle | 58 |
| Jauan Jennings | 54 |
| Ricky Pearsall | 50 |
| Christian McCaffrey | 48 |
| Demarcus Robinson | 18 |
Panthers vs. Niners game-day updates and essential details
The NFL Week 12 action between the 49ers and Panthers at Levi's Stadium is scheduled to start at 8:15PM ET.
- Who: Carolina Panthers vs. San Francisco 49ers
- Date: Monday, November 24, 2025
- Time: 8:15PM ET/5:15PM PT
- Venue: Levi's Stadium
NFL Week 12 betting promos and codes
Make the most of Dimers' Panthers vs. 49ers predictions by exploring the two exciting offers below.
DraftKings Sportsbook
Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.
Bet365 Sportsbook
Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.
Conclusion
We predict the 49ers, with a 75% win probability, will likely beat the Panthers in Week 12 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Panthers vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
Advertiser disclosure