Sabres vs. Penguins prediction: Why Pittsburgh is favored to win Wednesday's NHL matchup [11/26/2025]

The Pittsburgh Penguins will take on the Buffalo Sabres, in what is expected to be a tight NHL game, at PPG Paints Arena on Wednesday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' proven NHL model gives the Penguins a slight edge with a 53% win probability over the Sabres.

This article offers further insights into Wednesday's Sabres vs. Penguins matchup, including projected goal scorers, best bets and player prop picks.

Sabres vs. Penguins prediction: Who will win and cover?

As part of Dimers' NHL predictions coverage—and following a review of recent results—our pregame model has generated moneyline, puck line, and over/under probabilities for Wednesday's clash between the Sabres and Penguins.

Our famous predictive model currently gives the Penguins a 53% chance of defeating the Sabres.

According to our model, the Sabres (+1.5) have a 68% chance of covering the puck line, while the 6.5-goal over/under has a 53% chance of staying under.

Sabres vs. Penguins odds

We have researched the best NHL odds in America for this game, which are listed here:

Bet Type	Sabres	Penguins
Puck Line	+1.5 (-250)	-1.5 (+210)
Moneyline	+100	-110
Total	o6.5 (-102)	u6.5 (-115)

All odds are correct at the time of publication and are subject to change.

Sabres vs. Penguins picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Puck Line	Penguins -1.5	+210
Moneyline	Penguins	-110
Total	Under 6.5	-115

According to our NHL best bets, the top play to make on this game is Penguins to win.

Sabres vs. Penguins player props

Who will score a goal in Sabres vs. Penguins?

According to our model, Sidney Crosby is most likely to score an anytime goal in Sabres vs. Penguins.

Our projections give Crosby a 43.3% chance of scoring a goal at PPG Paints Arena, while the star is a 9.1% chance of netting the first goal the game.

Anytime goal scorer predictions

Buffalo Sabres

Player	Anytime Goal Probability
Tage Thompson	39.6%
Alex Tuch	28.8%
Jason Zucker	25.9%
Jack Quinn	23.3%
Zach Benson	20.8%

Pittsburgh Penguins

Player	Anytime Goal Probability
Sidney Crosby	43.3%
Anthony Mantha	32.4%
Evgeni Malkin	30.0%
Thomas Novak	27.7%
Ben Kindel	23.0%

First goal scorer predictions

Buffalo Sabres

Player	First Goal Probability
Tage Thompson	8.4%
Alex Tuch	5.3%
Jason Zucker	4.7%
Jack Quinn	3.7%
Ryan McLeod	3.6%

Pittsburgh Penguins

Player	First Goal Probability
Sidney Crosby	9.1%
Anthony Mantha	5.9%
Evgeni Malkin	5.5%
Thomas Novak	4.7%
Ben Kindel	4.3%

Sabres vs. Penguins game-day updates and essential details

Wednesday's matchup between the Penguins and Sabres at PPG Paints Arena is scheduled to begin at 7:00PM ET.

• Who: Buffalo Sabres vs. Pittsburgh Penguins
• Date: Wednesday, November 26, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: PPG Paints Arena

Conclusion

We predict the Penguins, with a 53% win probability, will likely beat the Sabres on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Sabres vs. Penguins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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