Buffalo Bills vs. New England Patriots updated prediction featuring James Cook, TreVeyon Henderson [Week 15, 2025]

Dimers' latest NFL predictions are live for New England Patriots vs. Buffalo Bills in Week 15, with our model giving the Bills a 57% of winning.

As Sunday approaches, both teams have updated their injury reports. Some lineup calls are still undecided, and those could shape how each side approaches this AFC East matchup.

Since our early Patriots-Bills predictions, we’ve updated the win probabilities, score projections, and TD odds for James Cook, TreVeyon Henderson, and others.

For the full simulation breakdown—including spreads, totals, touchdown probabilities, and the full list of player props—check out our Bills vs. Patriots page.

What's changed? Buffalo vs. New England updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Bills vs. Patriots matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Bills 57%, Patriots 43%
• Predicted Final Score: Bills 25-23 Patriots
• Spread: Bills (-1.5) 50%, Patriots (+1.5) 50%
• Total Points (50.5): Over 45%, Under 55%

As of December 11, 2025, these Bills-Patriots numbers reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 15 highlight the top candidates to find the end zone in Bills-Patriots on Sunday:

Buffalo Bills

• James Cook: 51.2% probability
• Josh Allen: 46.7% probability
• Khalil Shakir: 28.8% probability

New England Patriots

• TreVeyon Henderson: 48.0% probability
• Stefon Diggs: 35.1% probability
• Hunter Henry: 29.2% probability

Bills vs. Patriots latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Bills -1.5 (-102), Patriots +1.5 (-115)
• Moneyline: Bills -115, Patriots +100
• Total: Over/Under 50.5 (-110/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Bills vs. Patriots Week 15 details

The NFL Week 15 game between the Patriots and Bills at Gillette Stadium is scheduled for December 14, 2025.

• Who: Buffalo Bills vs. New England Patriots
• Date: Sunday, December 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Gillette Stadium

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Conclusion

We predict the Bills, with a 57% win probability, will likely beat the Patriots in Week 15 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Patriots matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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