Buffalo Bills vs. New England Patriots: Experts release early Week 15 projections [2025]

The Buffalo Bills and New England Patriots will meet in Week 15 of the NFL season at Gillette Stadium on Sunday, December 14, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this AFC East rivalry clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Patriots predictions page.

Buffalo vs. New England early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bills vs. Patriots game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bills 56%, Patriots 44%
• Predicted final score: Bills 24-22 Patriots
• Spread: Bills (-4.5) 38%, Patriots (+4.5) 62%
• Total points (48.5): Over 45%, Under 55%

As of December 8, 2025, these Bills-Patriots numbers and predictions reflect the latest data and insights available.

Bills vs. Patriots Week 15 details

The NFL Week 15 game between the Patriots and Bills at Gillette Stadium is scheduled for December 14, 2025.

• Who: Buffalo Bills vs. New England Patriots
• Date: Sunday, December 14, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Gillette Stadium

Bills vs. Patriots opening odds

We've researched the best betting odds across America for this Week 15 game, which are listed here:

• Spread: Bills -4.5 (-110), Patriots +4.5 (-110)
• Moneyline: Bills -102, Patriots +165
• Total: Over/Under 48.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 56% win probability, will likely beat the Patriots in Week 15 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Patriots game, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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