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Read Article Diamondbacks vs. Cardinals prediction: St. Louis favored to win Monday's MLB matchup [6/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Arizona Diamondbacks vs St. Louis Cardinals predictions for MLB Monday.
MLB action continues on Monday at 7:45 PM ET as the Arizona Diamondbacks take on the St. Louis Cardinals at Busch Stadium.
The Cardinals will have Andre Pallante (8-4, 3.76 ERA) as their starting pitcher, while the Diamondbacks are going with Merrill Kelly (5-6, 5.81 ERA).
Based on the latest simulations, Dimers' advanced MLB model gives the Cardinals a slight edge with a 54.4% win probability over the Diamondbacks.
This article offers a closer look at Monday's Diamondbacks vs. Cardinals matchup, including best bets and picks.
Diamondbacks vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the outcome of Monday's MLB matchup between the Diamondbacks and Cardinals, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Cardinals a 54.4% chance of defeating the Diamondbacks.
According to our model, the Diamondbacks (+1.5) have a 63.0% chance of covering the run line, while the over/under total of 8.5 runs has a 53.7% chance of going over,.
Diamondbacks vs. Cardinals odds [6/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Diamondbacks | Cardinals |
|---|---|---|
| Run Line | +1.5 (-170) | -1.5 (+146) |
| Moneyline | +120 | -142 |
| Total | o8.5 (-112) | u8.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Diamondbacks vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks +1.5 | -170 |
| Moneyline | Diamondbacks | +120 |
| Total | Over 8.5 | -112 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Diamondbacks vs. Cardinals game-day updates and essential details
Monday's MLB game between the Cardinals and Diamondbacks at Busch Stadium is scheduled to commence at 7:45 PM ET.
- Who: Arizona Diamondbacks vs. St. Louis Cardinals
- Date: Monday, June 22, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 54.4% win probability, will likely beat the Diamondbacks in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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