Diamondbacks vs. Reds Prediction: Arizona Predicted to Win Friday's MLB Matchup [6/6/2025]

The Cincinnati Reds will take on the Arizona Diamondbacks in MLB action at Great American Ball Park on Friday, beginning at 7:10PM ET.

Nick Lodolo (4-4, 3.10 ERA) will be on the bump for the Reds, pitting him against Eduardo Rodriguez (1-3, 7.05 ERA) for the Diamondbacks.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Diamondbacks as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Arizona-Cincinnati game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Diamondbacks' chance of winning is 52%, while the Reds' is 48%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Diamondbacks vs. Reds predictions page.

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Reds vs. Diamondbacks Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Diamondbacks and Reds 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Diamondbacks a 52% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 61% chance of covering the run line, while the over/under total of 9.5 runs has a 57% chance of staying under.

Diamondbacks vs. Reds Odds [6/6/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Diamondbacks vs. Reds Picks and Best Bets

Our model's biggest edge in today's Diamondbacks vs. Reds matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Diamondbacks vs. Reds Game-Day Updates and Essential Details

Friday's MLB matchup between the Reds and Diamondbacks at Great American Ball Park is scheduled to commence at 7:10PM ET.

• Who: Arizona Diamondbacks vs. Cincinnati Reds
• Date: Friday, June 6, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Great American Ball Park

Dimers.com's comprehensive preview of Friday's Diamondbacks vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Arizona vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Diamondbacks, with a 52% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Diamondbacks vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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