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Read Article Women's March Madness picks today: Sunday's Second Round best bets include Notre Dame vs. Ohio State play [3/22/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get women's March Madness picks and NCAA Tournament best bets for Sunday, March 22, 2026.
Today’s women's March Madness picks for March 22, 2026 are here, with Notre Dame vs. Ohio State and Illinois vs. Vanderbilt among the Second Round matchups identified as top value plays across Sunday’s women's NCAA Tournament schedule.
Dimers’ predictive analytics engine runs 24/7, going over the latest women's basketball odds to uncover real betting edges throughout the bracket. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of women's March Madness picks today [3/22, updated 10:33PM ET]
Below, you’ll find today’s top women's March Madness bets, ranked by edge for Sunday, March 22, 2026.
Ohio State ML (-230)
- Edge: 4.5%
- Probability: 74.2%
- Matchup: Notre Dame vs. Ohio State (4:00PM ET, Monday)
Our model has identified value on Ohio State to defeat Notre Dame at -230 odds. A 74.2% probability produces an edge of 4.5%, making this the strongest play for today's Second Round slate.
Illinois vs. Vanderbilt over 152.5 points (-110)
- Edge: 3.9%
- Probability: 56.2%
- Matchup: Illinois vs. Vanderbilt (7:00PM ET, Monday)
Illinois vs. Vanderbilt over 152.5 points carries a 3.9% edge and a probability of 56.2% at -110 odds, according to our model.
West Virginia ML (-180)
- Edge: 2.1%
- Probability: 66.4%
- Matchup: Kentucky vs. West Virginia (5:00PM ET, Monday)
West Virginia ML at -180 odds shows a 2.1% edge, supported by a 66.4% probability in simulations.
Ohio State -5.5 (-106)
- Edge: 2.1%
- Probability: 53.5%
- Matchup: Notre Dame vs. Ohio State (4:00PM ET, Monday)
A 2.1% edge and 53.5% probability make Ohio State -5.5 vs. Notre Dame at a value play in the Notre Dame vs. Ohio State matchup, per our model.
Women's March Madness best bets summary: Sunday, 3/22/2026
As of 10:33PM ET, here are our top women's March Madness bets by edge:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Notre Dame vs. Ohio State | Ohio State ML | -230 @ DraftKings | 4.5% | 74.2% |
| Illinois vs. Vanderbilt | Over 152.5 Points | -110 @ FanDuel | 3.9% | 56.2% |
| Kentucky vs. West Virginia | West Virginia ML | -180 @ DraftKings | 2.1% | 66.4% |
| Notre Dame vs. Ohio State | Ohio State -5.5 | -106 @ FanDuel | 2.1% | 53.5% |
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Conclusion
Today's women's March Madness best bets are locked and loaded for March 22, 2026, featuring plays such as Ohio State ML and over 152.5 points in the Illinois vs. Vanderbilt matchup. Powered by advanced simulations, these picks are here to boost your betting game.
All odds and probabilities in this article are correct and accurate at the time of publication.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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