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Women's March Madness picks today: Saturday's First Round best bets include James Madison vs. Kentucky play [3/21/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get women's March Madness picks and NCAA Tournament best bets for Saturday, March 21, 2026.
Today’s women's March Madness picks for March 21, 2026 are here, with James Madison vs. Kentucky and Syracuse vs. Iowa State among the First Round matchups identified as top value plays across Saturday’s women's NCAA Tournament play.
Dimers’ predictive analytics engine runs 24/7, going over the latest women's basketball odds to discover real betting edges throughout the bracket. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of women's March Madness picks today [3/21, updated 6:32AM ET]
Below, you’ll find today’s top women's March Madness bets, ranked by edge for Saturday, March 21, 2026.
James Madison ML (+1100)
- Edge: 7.6%
- Probability: 15.9%
- Matchup: James Madison vs. Kentucky (2:30PM ET, Saturday)
Our model has identified value on James Madison to defeat Kentucky at +1100 odds. A 15.9% probability produces an edge of 7.6%, making this the strongest play for today's First Round slate.
Syracuse ML (+245)
- Edge: 7.0%
- Probability: 36%
- Matchup: Syracuse vs. Iowa State (5:30PM ET, Saturday)
Syracuse ML carries a 7.0% edge and a probability of 36% at +245 odds, according to our model.
Illinois ML (-158)
- Edge: 4.7%
- Probability: 65.9%
- Matchup: Colorado vs. Illinois (9:30PM ET, Saturday)
Illinois ML at -158 odds shows a 4.7% edge, supported by a 65.9% probability in simulations.
Georgia ML (-132)
- Edge: 4.5%
- Probability: 61.4%
- Matchup: Virginia vs. Georgia (1:30PM ET, Saturday)
A 4.5% edge and 61.4% probability make Georgia at the moneyline at a value play in the Virginia vs. Georgia matchup, per our model.
Rhode Island ML (+410)
- Edge: 3.7%
- Probability: 23.4%
- Matchup: Rhode Island vs. Alabama (2:30PM ET, Saturday)
Rhode Island ML at +410 odds presents a 3.7% edge, with simulations resulting in a probability of 23.4%.
Women's March Madness best bets summary: Saturday, 3/21/2026
As of 6:32AM ET, here are our top women's March Madness bets by edge:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| James Madison vs. Kentucky | James Madison ML | +1100 @ DraftKings | 7.6% | 15.9% |
| Syracuse vs. Iowa State | Syracuse ML | +245 @ DraftKings | 7.0% | 36% |
| Colorado vs. Illinois | Illinois ML | -158 @ FanDuel | 4.7% | 65.9% |
| Virginia vs. Georgia | Georgia ML | -132 @ FanDuel | 4.5% | 61.4% |
| Rhode Island vs. Alabama | Rhode Island ML | +410 @ DraftKings | 3.7% | 23.4% |
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Conclusion
Today's women's March Madness best bets are locked and loaded for March 21, 2026, featuring plays such as James Madison ML and Syracuse ML. Powered by advanced simulations, these picks are here to boost your betting game.
All odds and probabilities in this article are correct and accurate at the time of publication.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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