Nationals vs. Padres Prediction: San Diego Predicted to Win Wednesday's MLB Matchup [6/25/2025]

The San Diego Padres will face the Washington Nationals in MLB action at PETCO Park on Wednesday, commencing at 4:10PM ET.

The Padres will send Nick Pivetta (7-2, 3.64 ERA) to the mound, while the Nationals will counter with MacKenzie Gore (3-7, 3.19 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Nationals-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 55%, with the Nationals at 45%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Nationals vs. Padres predictions page.

Padres vs. Nationals Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Nationals and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 55% chance of defeating the Nationals.

According to our model, the Nationals (+1.5) have a 65% chance of covering the run line, while the 7-run over/under has a 51% chance of going over.

Nationals vs. Padres Odds [6/25/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Nationals	Padres
Run Line	+1.5 (-186)	-1.5 (+160)
Moneyline	+123	-136
Total	o7 (-120)	u7 (+100)

All odds are correct at the time of publication and are subject to change.

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Nationals vs. Padres Picks and Best Bets

Our model's biggest edge in today's Nationals vs. Padres matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Nationals vs. Padres Game-Day Updates and Essential Details

Wednesday's MLB game between the Padres and Nationals at PETCO Park is scheduled to begin at 4:10PM ET.

• Who: Washington Nationals vs. San Diego Padres
• Date: Wednesday, June 25, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: PETCO Park

Dimers.com's full preview of Wednesday's Nationals vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Nationals vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Padres, with a 55% win probability, will likely beat the Nationals on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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