...
...
Read Article
- More Betting
VCU vs. USF prediction: Virginia Commonwealth favored to win men's college basketball matchup [11/26/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get VCU vs USF predictions for college basketball Wednesday.
Men's college basketball action continues on Wednesday at 2:30PM ET as VCU squares off with USF in men's college basketball action at Imperial Arena.
Based on updated simulation results, Dimers' advanced college basketball model gives Virginia Commonwealth a slight edge with a 53% win probability over South Florida.
This article offers further insights into Wednesday's VCU vs. USF matchup, including an expanded look at the predicted score, best bets and picks.
VCU vs. USF prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between VCU and USF 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model gives Virginia Commonwealth a 53% chance of defeating South Florida. Our predicted final score has Virginia Commonwealth winning 80-79.
According to our model, South Florida (+2.5) has a 58% chance of covering the spread, while the 172.5-point over/under has a 57% chance of staying under.
VCU vs. USF odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | VCU | USF |
|---|---|---|
| Spread | -2.5 (-106) | +2.5 (-110) |
| Moneyline | -148 | +126 |
| Total | o172.5 (-110) | u172.5 (-110) |
All odds are correct at the time of publication and are subject to change.
VCU vs. USF picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Florida +2.5 | -110 |
| Moneyline | South Florida | +126 |
| Total | Under 172.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is South Florida +2.5 at the spread.
VCU vs. USF game-day updates and essential details
Wednesday's men's college basketball matchup between USF and VCU at Imperial Arena is scheduled to start at 2:30PM ET.
- Who: Virginia Commonwealth vs. South Florida
- Date: Wednesday, November 26, 2025
- Time: 2:30PM ET/11:30AM PT
- Venue: Imperial Arena
Conclusion
We predict Virginia Commonwealth, with a 53% win probability, will likely beat South Florida on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Virginia Commonwealth vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure