Vanderbilt vs. Memphis prediction: Why Vanderbilt is favored to win men's college basketball matchup [12/17/2025]

Memphis and Vanderbilt will meet in men's college basketball action at FedExForum on Wednesday, with tipoff at 7:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Vanderbilt as the most likely winner of the Vanderbilt vs. Memphis game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Vanderbilt vs. Memphis prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between Vanderbilt and Memphis 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Vanderbilt a 72% chance of beating Memphis. Our predicted final score has Vanderbilt winning 82-75.

According to our model, Memphis (+7.5) has a 55% chance of covering the spread, while the over/under total of 158.5 points has an equal 50-50 chance of hitting.

Vanderbilt vs. Memphis odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Vanderbilt vs. Memphis picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: