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USC vs. Notre Dame prediction: Notre Dame favored to win women's college basketball matchup [11/21/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get USC vs Notre Dame predictions for college basketball Friday.
Notre Dame and USC will lock horns in the women's college basketball at Purcell Pavilion on Friday, starting at 6:00PM ET.
Based on updated simulations, Dimers' new women's basketball model predicts Notre Dame as the most likely winner of the USC vs. Notre Dame game.
This article offers an expanded analysis of Friday's matchup, including best bets and picks.
USC vs. Notre Dame prediction: Who will win?
Using innovative machine learning and data, we have simulated the result of Friday's women's basketball matchup between USC and Notre Dame 10,000 times as part of our women's college basketball predictions coverage.
Our famous predictive model gives Notre Dame a 57% chance of defeating USC.
According to our model, the 143.5-point over/under has a 51% chance of staying under.
USC vs. Notre Dame odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | USC | Notre Dame |
|---|---|---|
| Spread | -1.5 (-110) | +1.5 (-110) |
| Moneyline | +108 | -110 |
| Total | o143.5 (-110) | u143.5 (-110) |
All odds are correct at the time of publication and are subject to change.
USC vs. Notre Dame picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Notre Dame +1.5 | -110 |
| Moneyline | Notre Dame | -110 |
| Total | Under 143.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Notre Dame to win.
USC vs. Notre Dame game-day updates and essential details
Friday's women's basketball action between Notre Dame and USC at Purcell Pavilion is scheduled to commence at 6:00PM ET.
- Who: USC vs. Notre Dame
- Date: Friday, November 21, 2025
- Time: 6:00PM ET/3:00PM PT
- Venue: Purcell Pavilion
Conclusion
We predict Notre Dame, with a 57% win probability, will likely beat USC on Friday.
AI and automation have enhanced this article to quickly deliver accurate USC vs. Notre Dame insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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