USC Upstate vs. Charleston Southern prediction: Why Charleston Southern is favored to win men's college basketball matchup [1/14/2026]

Charleston Southern will square off with USC Upstate in men's college basketball action at The Buc Dome on Wednesday, commencing at 7:00 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts Charleston Southern as the most likely winner of the USC Upstate vs. Charleston Southern game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

USC Upstate vs. Charleston Southern prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball game between USC Upstate and Charleston Southern 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Charleston Southern a 74% chance of defeating USC Upstate. Our predicted final score has Charleston Southern winning 80-73.

According to our model, Charleston Southern (-6.5) has a 55% chance of covering the spread, while the over/under total of 154.5 points has an equal 50-50 chance of hitting.

USC Upstate vs. Charleston Southern odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

USC Upstate vs. Charleston Southern picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: