Blue Jays vs. Mariners prediction: Seattle favored to win Game 4 of ALCS [10/16/2025]

The Seattle Mariners and Toronto Blue Jays will meet in Game 4 of the American League Championship Series at T-Mobile Park on Thursday, starting at 8:33PM ET.

The Mariners will start Luis Castillo (1-0, 0.00 ERA in 2025 postseason), pitting him against Max Scherzer (0-0, 0.00 ERA) for the Blue Jays.

Based on the latest simulation results, Dimers' proven MLB model projects the Mariners as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Blue Jays vs. Mariners predictions page.

Blue Jays vs. Mariners prediction: Who will win Game 4?

Using innovative machine learning and data, we have simulated the result of Thursday's MLB game between the Blue Jays and Mariners 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Mariners a 56% chance of defeating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 62% chance of covering the run line, while the 7.5-run over/under has a 64% chance of going over.

Blue Jays vs. Mariners Game 4 odds [10/16/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Blue Jays	Mariners
Run Line	+1.5 (-199)	-1.5 (+168)
Moneyline	+112	-130
Total	o7.5 (-108)	u7.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Blue Jays vs. Mariners picks and best bets for Game 4

Our model's strongest edge in today's Blue Jays vs. Mariners matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Blue Jays vs. Mariners game-day updates and essential details

Thursday's MLB game between the Mariners and Blue Jays at T-Mobile Park is scheduled to commence at 8:33PM ET.

• Who: Toronto Blue Jays vs. Seattle Mariners
• Date: Thursday, October 16, 2025
• Time: 8:33PM ET/5:33PM PT
• Venue: T-Mobile Park

Dimers' full preview of Thursday's Blue Jays vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Blue Jays vs. Mariners picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Mariners, with a 56% win probability, will likely beat the Blue Jays on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Blue Jays vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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