Tennessee vs. Louisville prediction: Tennessee favored to win women's college basketball matchup [12/20/2025]

Women's college basketball action continues on Saturday at 11:00 AM ET as Tennessee takes on Louisville at Barclays Center.

Based on updated simulations, Dimers' new women's basketball model projects Tennessee as the most likely winner of the Tennessee vs. Louisville game.

This article offers further insights into Saturday's matchup, including best bets and picks.

Tennessee vs. Louisville prediction: Who will win?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's women's basketball matchup between Tennessee and Louisville 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model gives Tennessee a 63% chance of defeating Louisville.

According to our model, the over/under total of 148.5 points has a 52% chance of going over.

Tennessee vs. Louisville odds

We have sourced the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Tennessee vs. Louisville picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: