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Titans vs. 49ers prediction: San Francisco favored to win in NFL Week 15 [2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Tennessee Titans vs San Francisco 49ers predictions for NFL Sunday.
The San Francisco 49ers will square off with the Tennessee Titans in NFL Week 15 action at Levi's Stadium on Sunday, starting at 4:25PM ET.
Based on updated simulation results, Dimers' advanced NFL model predicts the 49ers as the most likely winner of the Titans vs. 49ers game.
This article offers an expanded analysis of Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.
Titans vs. Niners prediction: Who will win and cover?
Since our Titans-49ers predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Titans and 49ers 10,000 times as part of our NFL predictions coverage.
Our leading predictive model gives the 49ers an 87% chance of defeating the Titans in Week 15 of the NFL season. Our predicted final score has the 49ers winning 27-16.
According to our model, the Titans (+12.5) have a 52% chance of covering the spread, while the over/under total of 44.5 points has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 15 straight up picks.
Titans vs. 49ers odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Titans | 49ers |
|---|---|---|
| Spread | +12.5 (-105) | -12.5 (-112) |
| Moneyline | +640 | -900 |
| Total | o44.5 (-106) | u44.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Titans vs. 49ers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Titans +12.5 | -105 |
| Moneyline | Titans | +640 |
| Total | Over 44.5 | -106 |
According to our NFL best bets, the top play to make on this game is Titans +12.5 at the spread.
Titans vs. 49ers TD scorers
Who will score a touchdown in Titans vs. 49ers?
According to our list of touchdown scorer predictions for Week 15, Christian McCaffrey is most likely to score an anytime touchdown in Titans vs. 49ers.
Our projections give McCaffrey a 66.6% chance of scoring a TD at Levi's Stadium, while the running back is a 20.6% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
Tennessee Titans
| Player | Anytime TD Probability |
|---|---|
| Tyjae Spears (RB) | 23.3% |
| Tony Pollard (RB) | 23.0% |
| Chimere Dike (WR) | 22.6% |
| Elic Ayomanor (WR) | 21.4% |
| Gunnar Helm (TE) | 14.5% |
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey (RB) | 66.6% |
| George Kittle (TE) | 39.8% |
| Jauan Jennings (WR) | 33.2% |
| Ricky Pearsall (WR) | 24.9% |
| Brian Robinson (RB) | 22.1% |
First touchdown scorer predictions
Tennessee Titans
| Player | First TD Probability |
|---|---|
| Tyjae Spears (RB) | 5.7% |
| Tony Pollard (RB) | 5.6% |
| Chimere Dike (WR) | 5.5% |
| Elic Ayomanor (WR) | 5.1% |
| Gunnar Helm (TE) | 3.4% |
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey (RB) | 20.6% |
| George Kittle (TE) | 9.5% |
| Jauan Jennings (WR) | 7.6% |
| Ricky Pearsall (WR) | 5.4% |
| Brian Robinson (RB) | 4.7% |
Titans vs 49ers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Titans and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 15 games.
Quarterbacks
Of the starting quarterbacks, the Titans' Cam Ward is projected for 205 passing yards, while the 49ers' Brock Purdy is expected to throw for 245 yards.
| Player | Proj. Pass Yards |
|---|---|
| Cam Ward (TEN) | 205 |
| Brock Purdy (SF) | 245 |
Titans rushing
| Player | Proj. Rush Yards |
|---|---|
| Tony Pollard | 51 |
| Tyjae Spears | 22 |
| Cam Ward | 13 |
49ers rushing
| Player | Proj. Rush Yards |
|---|---|
| Christian McCaffrey | 69 |
| Brian Robinson | 32 |
| Brock Purdy | 12 |
Titans receiving
| Player | Proj. Rec. Yards |
|---|---|
| Chimere Dike | 38 |
| Elic Ayomanor | 37 |
| Gunnar Helm | 28 |
| Chig Okonkwo | 28 |
| Van Jefferson | 27 |
49ers receiving
| Player | Proj. Rec. Yards |
|---|---|
| George Kittle | 61 |
| Jauan Jennings | 54 |
| Ricky Pearsall | 45 |
| Christian McCaffrey | 44 |
| Demarcus Robinson | 18 |
Titans vs. Niners game-day updates and essential details
The NFL Week 15 action between the 49ers and Titans at Levi's Stadium is scheduled to start at 4:25PM ET.
- Who: Tennessee Titans vs. San Francisco 49ers
- Date: Sunday, December 14, 2025
- Time: 4:25PM ET/1:25PM PT
- Venue: Levi's Stadium
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Conclusion
We predict the 49ers, with an 87% win probability, will likely beat the Titans in Week 15 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Titans vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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