NFL picks straight up: Week 15, 2025

At Dimers.com, we provide NFL picks straight up for Week 15 and beyond, as part of our in-depth NFL picks and NFL predictions coverage.

With Week 15 of the NFL season here, we've used our dynamic predictive analytics model to deliver a list of NFL straight up picks for all 16 games this week.

Get an advantage in your NFL pick 'em contests via our data-driven NFL Week 15 picks straight up, powered by thousands of game simulations.

Week 15 of the NFL season features 16 games, starting with the Atlanta Falcons facing the Tampa Bay Buccaneers on Thursday night and wrapping up with the Miami Dolphins taking on the Pittsburgh Steelers on Monday night.

Before placing any NFL wagers this week, be sure to explore our full list of NFL best bets with Dimers Pro.

Sign up with code 20FOOTBALL at checkout right now to receive 20% off your first month of Dimers Pro! This offer won't last forever.

Our data-driven approach ensures you have the tools you need for every NFL game, every week. Subscribe now and start betting smarter.

Full list of NFL Week 15 picks straight up

• Buccaneers (68% win probability)
• Giants (58%)
• Eagles (89%)
• Bears (78%)
• Ravens (56%)
• Texans (79%)
• Bills (56%)
• Jaguars (87%)
• Chiefs (67%)
• Seahawks (89%)
• 49ers (86%)
• Packers (57%)
• Panthers (60%)
• Rams (67%)
• Cowboys (73%)
• Steelers (60%)

NFL picks this week straight up: Week 15, 2025

Listed below are our Week 15 NFL picks, highlighting each team's chances of winning their game this week.

Atlanta Falcons vs. Tampa Bay Buccaneers

The Falcons kick off Week 15 against the Buccaneers at Raymond James Stadium on Thursday night. According to our NFL model, the Buccaneers have a 68% chance of winning, while the Falcons have a 32% chance.

For Week 15's opening game, our model highlights NFL player props with Bijan Robinson (RB) as the most likely player from the Falcons to score the first TD at 11.6%, while Mike Evans (WR) is the top candidate from the Buccaneers at 11.1%.

The Atlanta Falcons vs. Tampa Bay Buccaneers game at Raymond James Stadium is scheduled for Thursday, December 11 at 8:15pm. All times mentioned in this article are in Eastern Standard Time (EST).

Washington Commanders vs. New York Giants

For this week's game between the Commanders and the Giants, NY Giants is more likely to win. Our prediction model gives the Giants a 58% chance of winning. On the other hand, there is a 42% chance that the Commanders will win.

The Washington Commanders vs. New York Giants matchup at MetLife Stadium will take place on Sunday, December 14 at 1:00pm.

As the playoffs apporoach, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

Las Vegas Raiders vs. Philadelphia Eagles

We are picking the Eagles to win their game against the Raiders this week, with our famous NFL model projecting an 89% win probability for the home team. The Raiders have a 11% chance of winning at Lincoln Financial Field.

For betting purposes, the Eagles are listed as -12.5 favorites, with the Raiders' moneyline at +660.

The Las Vegas Raiders vs. Philadelphia Eagles game at Lincoln Financial Field is slated for Sunday, December 14 at 1:00pm.

Cleveland Browns vs. Chicago Bears

According to our predictive analytics model, the Bears are the team to beat in this game, with their win probability at 78%. The Browns, on the other hand, have a 22% chance of winning.

The Cleveland Browns vs. Chicago Bears game at Soldier Field is set for Sunday, December 14 at 1:00pm.

Baltimore Ravens vs. Cincinnati Bengals

The Ravens have a 56% chance of winning on Sunday afternoon, compared to the Bengals' 44% chance of victory. This makes the Baltimore Ravens our pick to win at Paycor Stadium.

The Baltimore Ravens vs. Cincinnati Bengals matchup at Paycor Stadium is scheduled for Sunday, December 14 at 1:00pm.

Arizona Cardinals vs. Houston Texans

The Texans are favorites to win their Week 15 game, with our predictive analytics model giving them a 79% chance, while the Cardinals enter the weekend with a 21% chance of causing an upset at NRG Stadium.

When it comes to betting on this game, the Cardinals' moneyline odds are set at +440, with the home team Texans listed as -9.5 favorites.

The Arizona Cardinals vs. Houston Texans game at NRG Stadium will take place on Sunday, December 14 at 1:00pm.

Buffalo Bills vs. New England Patriots

After 10,000 simulations of Bills vs. Patriots this Sunday, our model projects the Bills as the more likely winners with a probability of 56%. Their opponents, the Patriots, have a 44% chance of getting the win at home.

The Buffalo Bills vs. New England Patriots matchup at Gillette Stadium is slated for Sunday, December 14 at 1:00pm.

New York Jets vs. Jacksonville Jaguars

We are picking the Jaguars, who have an 87% chance of winning the matchup, while the Jets have a 13% win probability.

The New York Jets vs. Jacksonville Jaguars game at EverBank Stadium will take place on Sunday, December 14 at 1:00pm.

Los Angeles Chargers vs. Kansas City Chiefs

The next game of Week 15 sees the Chargers take on the Chiefs at GEHA Field at Arrowhead Stadium.

We predict the Chiefs to win with a probability of 67%, while the Chargers are projected to have a win chance of 33%.

As for the Vegas betting odds here, the Chiefs are listed as -3.5 favorites, with the Chargers' moneyline odds posted at +180.

The Los Angeles Chargers vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium is scheduled for Sunday, December 14 at 1:00pm.

Indianapolis Colts vs. Seattle Seahawks

The likely winner of this matchup is the Seahawks, who have a projected win chance of 89%, according to DimersBOT. On the other side of this matchup, the Colts have a projected win probability of 11%.

The Indianapolis Colts vs. Seattle Seahawks matchup at Lumen Field is set for Sunday, December 14 at 4:25pm.

Tennessee Titans vs. San Francisco 49ers

We have run our powerful NFL model over this week’s Titans-49ers clash 10,000 times, with the 49ers coming out as the team to pick. Of those 10,000 simulations, the 49ers won 8,649 times, with the Titans winning on 1,351 occasions.

The Tennessee Titans vs. San Francisco 49ers game at Levi's Stadium is scheduled for Sunday, December 14 at 4:25pm.

Green Bay Packers vs. Denver Broncos

Next up is the game between the Packers and Broncos, with our model projecting the road team as the more likely victor, with the Packers rated as having a 57% chance of getting the W. The Broncos, on the other hand, are projected to have a 43% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Packers' moneyline odds set at -135 for this road game, while the hosting Broncos are listed as +2.5 underdogs.

The Green Bay Packers vs. Denver Broncos game at Empower Field at Mile High will take place on Sunday, December 14 at 4:25pm.

Carolina Panthers vs. New Orleans Saints

Our next straight up pick this week is for the Panthers to get the win against the Saints. After running 10,000 simulations of this matchup, the Carolina have a win probability of 60%, with the Saints at 40%.

The Carolina Panthers vs. New Orleans Saints game at Caesars Superdome is slated for Sunday, December 14 at 4:25pm.

Detroit Lions vs. Los Angeles Rams

With a win probability of 67% on Sunday afternoon, our straight up pick for this matchup is the Rams, while their opponent, the Lions, have a projected win chance of 33%.

The Detroit Lions vs. Los Angeles Rams game at SoFi Stadium will take place on Sunday, December 14 at 4:25pm.

For a different angle on this week's NFL action, explore Dimers' NFL trends to find the latest player prop trends.

Minnesota Vikings vs. Dallas Cowboys

The team to pick here is the Cowboys, who have a 73% chance of winning their matchup against the Vikings this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Cowboys are listed as -6 favorites at home, with the Vikings' moneyline odds available at +250.

The Minnesota Vikings vs. Dallas Cowboys game at AT&T Stadium is scheduled for Sunday, December 14 at 8:20pm.

Miami Dolphins vs. Pittsburgh Steelers

Our pick to win the final game of Week 15 is the Steelers, who have a win probability of 60%. Their opponents are projected to have a 40% chance of getting the W.

The Miami Dolphins vs. Pittsburgh Steelers game at Acrisure Stadium is set for Monday, December 15 at 8:15pm.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 15

The NFL Week 15 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

If you choose to use our NFL straight up picks for betting, it's crucial to gamble responsibly and know when to stop. For more resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities mentioned on this page are subject to change.