Tampa Bay Buccaneers vs. Buffalo Bills updated prediction featuring Rachaad White, James Cook [Week 11, 2025]

Dimers' latest NFL predictions are live for Buffalo Bills vs. Tampa Bay Buccaneers in Week 11, with our model giving the Bills a 68% of winning on Sunday.

In the days leading up to kickoff, both teams have made adjustments to their official injury reports, with lineup decisions and player conditions still taking shape in the final days before kickoff. These updates could influence how each side approaches key matchups in this cross-conference meeting.

Building on those developments, we have fresh updates since our early Bills-Buccaneers predictions, delivering renewed win probabilities, score projections, and TD predictions for Rachaad White, James Cook, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our Buccaneers vs. Bills page.

What's changed? Tampa Bay vs. Buffalo updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Bucs vs. Bills matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: Buccaneers 32%, Bills 68%
• Predicted Final Score: Buccaneers 21-26 Bills
• Spread: Buccaneers (+5.5) 50%, Bills (-5.5) 50%
• Total Points (47.5): Over 50%, Under 50%

As of November 13, 2025, these Buccaneers-Bills figures reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 11 highlight the top candidates to find the end zone in Bucs-Bills on Sunday:

Tampa Bay Buccaneers

• Rachaad White: 43.0% probability
• Emeka Egbuka: 37.5% probability
• Sean Tucker: 30.4% probability

Buffalo Bills

• James Cook: 55.9% probability
• Josh Allen: 48.4% probability
• Khalil Shakir: 32.4% probability

Bucs vs. Bills latest odds

The best current odds from the top sportsbooks in the US:

• Spread: Buccaneers +5.5 (-110), Bills -5.5 (-110)
• Moneyline: Buccaneers +220, Bills -250
• Total: Over/Under 47.5 (-120/-102)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Bucs vs. Bills Week 11 details

The NFL Week 11 action between the Bills and Buccaneers at Highmark Stadium is scheduled for November 16, 2025.

• Who: Tampa Bay Buccaneers vs. Buffalo Bills
• Date: Sunday, November 16, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium

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Conclusion

We predict the Bills, with a 68% win probability, will likely beat the Buccaneers in Week 11 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Buccaneers vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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