Tampa Bay Buccaneers vs. Buffalo Bills: Experts release early Week 11 preview [2025]

The Tampa Bay Buccaneers and Buffalo Bills will meet in Week 11 of the NFL season at Highmark Stadium on Sunday, November 16, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this cross-conference meeting.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Buccaneers vs. Bills predictions page.

Tampa Bay vs. Buffalo early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bucs vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Buccaneers 32%, Bills 68%
• Predicted final score: Buccaneers 22-27 Bills
• Spread: Buccaneers (+5.5) 50%, Bills (-5.5) 50%
• Total points (49.5): Over 50%, Under 50%

As of November 10, 2025, these Buccaneers-Bills numbers and predictions reflect the latest data and insights available.

Bucs vs. Bills Week 11 details

The NFL Week 11 matchup between the Bills and Buccaneers at Highmark Stadium is scheduled for November 16, 2025.

• Who: Tampa Bay Buccaneers vs. Buffalo Bills
• Date: Sunday, November 16, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium

Bucs vs. Bills opening odds

We've researched the best betting odds across America for this Week 11 game, which are listed here:

• Spread: Buccaneers +5.5 (-110), Bills -5.5 (-110)
• Moneyline: Buccaneers +215, Bills -245
• Total: Over/Under 49.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 11 highlight the top candidates to score a TD in Bucs-Bills in Week 11:

Tampa Bay Buccaneers

• Rachaad White: 56.7% probability
• Emeka Egbuka: 43.0% probability
• Tez Johnson: 32.6% probability

Buffalo Bills

• James Cook: 57.8% probability
• Josh Allen: 49.5% probability
• Khalil Shakir: 33.6% probability

Buccaneers vs Bills player props

Rachaad White is projected to lead rushing for the Buccaneers, while James Cook is expected to pace the Bills on the ground.

In the receiving game, our projections favor Tampa Bay's Emeka Egbuka and Buffalo's Khalil Shakir as the likely leaders for each team.

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Conclusion

We predict the Bills, with a 68% win probability, will likely beat the Buccaneers in Week 11 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Buccaneers vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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