Syracuse vs. Clemson Prediction: Clemson Predicted to Win College Basketball Matchup [1/22/2025]

Clemson will face Syracuse in college basketball action at Littlejohn Coliseum on Wednesday, starting at 7:00PM ET.

Based on the latest simulation results, Dimers' proven college basketball model (see Dimers Pro for full access) predicts Clemson as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Syracuse-Clemson game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate Clemson's chance of winning at 93%, with Syracuse at 7%."

For a closer look at Wednesday's matchup, including the predicted score, best bets and an expanded look at the predicted final score, visit our interactive Syracuse vs. Clemson predictions page.

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Syracuse vs. Clemson Game-Day Updates and Essential Details

Wednesday's college basketball action between Clemson and Syracuse at Littlejohn Coliseum is scheduled to start at 7:00PM ET.

• Who: Syracuse vs. Clemson
• Date: Wednesday, January 22, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Littlejohn Coliseum
• Tickets: Get tickets for the game on Ticketmaster

Dimers.com's full preview of Wednesday's Syracuse vs. Clemson matchup includes our prediction, picks and the latest betting odds.

Before making any Syracuse vs. Clemson picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

Syracuse vs. Clemson Prediction: Who Will Win, Cover the Spread?

Using trusted machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball game between Syracuse and Clemson 10,000 times as part of our college basketball predictions coverage.

Our leading predictive model currently gives Clemson a 93% chance of beating Syracuse. Our predicted final score has Clemson winning 79-62.

According to our model, the bookmakers have got it right, and Syracuse and Clemson each have a 50% chance of covering the spread, while the over/under total of 141.5 points has a 54% chance of going over.

Pre-Game Probabilities

Last Updated: 11:46PM, Jan 22

Spread

Over / Under

Moneyline

Syracuse

Clemson -16.5

50%

50%

-120

+100

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Clemson

Syracuse SYR

-120

Clemson -16.5

50%

50%

See Matchup

Clemson CLEM

+100

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Syracuse vs. Clemson Odds

We have sourced the best betting odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Syracuse vs. Clemson Picks

Our model's strongest edge in today's Syracuse vs. Clemson matchup is on the spread.

Our expert predictions, aligned with the latest odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Conclusion

We predict Clemson, with a 93% win probability, will likely beat Syracuse on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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