Cardinals vs. Giants prediction: Cy Young candidate Logan Webb takes on St. Louis tonight [9/23/2025]

The San Francisco Giants and St. Louis Cardinals will meet in MLB action at Oracle Park on Tuesday, starting at 9:45PM ET.

Cy Young hopeful Logan Webb (14-11, 3.27 ERA) will be on the bump for the Giants, while the Cardinals have opted for Andre Pallante (6-15, 5.29 ERA).

Based on updated simulations, Dimers' proven MLB model predicts the Giants as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Cardinals vs. Giants predictions page.

Giants vs. Cardinals prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Cardinals and Giants 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Giants a 63% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 56% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.

Cardinals vs. Giants odds [9/23/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Cardinals	Giants
Run Line	+1.5 (-128)	-1.5 (+110)
Moneyline	+168	-200
Total	o7.5 (-110)	u7.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Cardinals vs. Giants picks and best bets

Our model's strongest edge in today's Cardinals vs. Giants matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Cardinals vs. Giants game-day updates and essential details

Tuesday's MLB action between the Giants and Cardinals at Oracle Park is scheduled to begin at 9:45PM ET.

• Who: St. Louis Cardinals vs. San Francisco Giants
• Date: Tuesday, September 23, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers' in-depth preview of Tuesday's Cardinals vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cardinals vs. Giants picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 63% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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