St. John's vs. DePaul prediction: St. John's favored to win men's college basketball matchup [2/3/2026]

Men's college basketball action continues on Tuesday at 8:00 PM ET as the favored St. John's locks horns with DePaul in men's college basketball action at Wintrust Arena.

Based on updated simulations, Dimers' proven college basketball model projects St. John's as the most likely winner of the St. John's vs. DePaul game.

This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

St. John's vs. DePaul prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball game between St. John's and DePaul 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives St. John's an 83% chance of beating DePaul. Our predicted final score has St. John's winning 77-68.

According to our model, DePaul (+10.5) has a 54% chance of covering the spread, while the over/under total of 145.5 points has a 52% chance of going over.

St. John's vs. DePaul odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

St. John's vs. DePaul picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: