St. John's vs. Creighton prediction: Why St. John's is favored to win men's college basketball matchup [1/10/2026]

Creighton will face St. John's, in what is expected to be a tight Men's College Basketball game, at CHI Health Center Omaha on Saturday, beginning at 2:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model gives St. John's a slight edge with a 53% win probability over Creighton.

This article offers an expanded analysis of Saturday's St. John's vs. Creighton matchup, including an expanded look at the predicted score, best bets and picks.

St. John's vs. Creighton prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAA basketball game between St. John's and Creighton 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives St. John's a 53% chance of beating Creighton. Our predicted final score has St. John's winning 77-76.

According to our model, Creighton (+2.5) has a 55% chance of covering the spread, while the 152.5-point over/under has a 53% chance of going over.

St. John's vs. Creighton odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

St. John's vs. Creighton picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: