Southern University vs. San Jose State prediction: San Jose State favored to win men's college basketball matchup [11/21/2025]

San Jose State will face Southern University in men's college basketball action at Provident Credit Union Event Center on Friday, beginning at 10:00PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts San Jose State as the most likely winner of the Southern University vs. San Jose State game.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern University vs. San Jose State prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's NCAA basketball matchup between Southern University and San Jose State 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives San Jose State a 71% chance of beating Southern University. Our predicted final score has San Jose State winning 78-72.

According to our model, San Jose State (-5.5) has a 51% chance of covering the spread, while the 149.5-point over/under has a 52% chance of going over.

Southern University vs. San Jose State odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern University vs. San Jose State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is San Jose State to win.

Southern University vs. San Jose State game-day updates and essential details

Friday's men's college basketball game between San Jose State and Southern University at Provident Credit Union Event Center is scheduled to start at 10:00PM ET.

• Who: Southern University vs. San Jose State
• Date: Friday, November 21, 2025
• Time: 10:00PM ET/7:00PM PT
• Venue: Provident Credit Union Event Center

Conclusion

We predict San Jose State, with a 71% win probability, will likely beat Southern University on Friday.

AI and automation have enhanced this article to quickly deliver accurate Southern University vs. San Jose State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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