Southern University vs. Marquette prediction: Why Marquette is favored to win men's college basketball matchup [11/5/2025]

Marquette will face Southern University in men's college basketball action at Fiserv Forum on Wednesday, starting at 8:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Marquette as the most likely winner of the Southern University vs. Marquette game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern University vs. Marquette prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between Southern University and Marquette 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Marquette a 97% chance of defeating Southern University. Our predicted final score has Marquette winning 88-65.

According to our model, Southern University (+24.5) has a 53% chance of covering the spread, while the over/under total of 154.5 points has a 53% chance of staying under.

Southern University vs. Marquette odds

We have sourced the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern University vs. Marquette picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Southern University +24.5 at the spread.

Southern University vs. Marquette game-day updates and essential details

Wednesday's men's college basketball matchup between Marquette and Southern University at Fiserv Forum is scheduled to begin at 8:00PM ET.

• Who: Southern University vs. Marquette
• Date: Wednesday, November 5, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Fiserv Forum

Conclusion

We predict Marquette, with a 97% win probability, will likely beat Southern University on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Southern University vs. Marquette insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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