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Southern University vs. Iowa State prediction: Why Iowa State is favored to win women's college basketball matchup [11/5/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Southern University vs Iowa State predictions for college basketball Wednesday.
Iowa State will square off with Southern University in women's college basketball action at James H. Hilton Coliseum on Wednesday, starting at 7:30PM ET.
Based on the latest simulation results, Dimers' new women's college basketball model predicts Iowa State as the most likely winner of the Southern University vs. Iowa State game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Southern University vs. Iowa State prediction: Who will win?
Using powerful machine learning and data, we have simulated the result of Wednesday's women's college basketball game between Southern University and Iowa State 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model gives Iowa State a 99% chance of defeating Southern University.
According to our model, the over/under total of 134.5 points has a 56% chance of staying under.
Southern University vs. Iowa State odds
We have sourced the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Southern University | Iowa State |
|---|---|---|
| Spread | +39.5 (-110) | -39.5 (-110) |
| Total | o134.5 (-110) | u134.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Southern University vs. Iowa State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern University +39.5 | -110 |
| Total | Under 134.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Southern University +39.5.
Southern University vs. Iowa State game-day updates and essential details
Wednesday's women's college basketball action between Iowa State and Southern University at James H. Hilton Coliseum is scheduled to begin at 7:30PM ET.
- Who: Southern University vs. Iowa State
- Date: Wednesday, November 5, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: James H. Hilton Coliseum
Conclusion
We predict Iowa State, with a 99% win probability, will likely beat Southern University on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Southern University vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on women's college basketball
Keep up with the latest women's college basketball news and WCBB parlay picks throughout the season.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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