Southern Miss vs. South Carolina prediction: South Carolina favored to win men's college basketball matchup [11/9/2025]

South Carolina will face Southern Miss in men's college basketball action at Colonial Life Arena on Sunday, commencing at 6:30PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts South Carolina as the most likely winner of the Southern Miss vs. South Carolina game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Miss vs. South Carolina prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Sunday's NCAA basketball matchup between Southern Miss and South Carolina 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives South Carolina a 94% chance of defeating Southern Miss. Our predicted final score has South Carolina winning 81-64.

According to our model, Southern Miss (+17.5) has a 51% chance of covering the spread, while the 146.5-point over/under has a 53% chance of staying under.

Southern Miss vs. South Carolina odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Miss vs. South Carolina picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Under 146.5 total points.

Southern Miss vs. South Carolina game-day updates and essential details

Sunday's men's college basketball matchup between South Carolina and Southern Miss at Colonial Life Arena is scheduled to commence at 6:30PM ET.

• Who: Southern Miss vs. South Carolina
• Date: Sunday, November 9, 2025
• Time: 6:30PM ET/3:30PM PT
• Venue: Colonial Life Arena

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Conclusion

We predict South Carolina, with a 94% win probability, will likely beat Southern Miss on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Southern Miss vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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