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Southern Indiana vs. Illinois-Chicago prediction: Why Illinois-Chicago is favored to win men's college basketball matchup [11/22/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Southern Indiana vs Illinois-Chicago predictions for college basketball Saturday.
Men's college basketball action continues on Saturday at 5:00PM ET as Southern Indiana squares off with Illinois-Chicago in men's college basketball action at Ocean Center.
Based on the latest simulations, Dimers' advanced college basketball model projects Illinois-Chicago as the most likely winner of the Southern Indiana vs. Illinois-Chicago game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Southern Indiana vs. Illinois-Chicago prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball matchup between Southern Indiana and Illinois-Chicago 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model gives Illinois-Chicago an 81% chance of beating Southern Indiana. Our predicted final score has Illinois-Chicago winning 80-71.
According to our model, Southern Indiana (+11.5) has a 54% chance of covering the spread, while the over/under total of 153.5 points has a 53% chance of staying under.
Southern Indiana vs. Illinois-Chicago odds
We have sourced the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | Southern Indiana | Illinois-Chicago |
|---|---|---|
| Spread | +11.5 (-110) | -11.5 (-108) |
| Moneyline | +550 | -750 |
| Total | o153.5 (-110) | u153.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Southern Indiana vs. Illinois-Chicago picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Southern Indiana +11.5 | -110 |
| Moneyline | Southern Indiana | +550 |
| Total | Under 153.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Southern Indiana to win.
Southern Indiana vs. Illinois-Chicago game-day updates and essential details
Saturday's men's college basketball game between Illinois-Chicago and Southern Indiana at Ocean Center is scheduled to begin at 5:00PM ET.
- Who: Southern Indiana vs. Illinois-Chicago
- Date: Saturday, November 22, 2025
- Time: 5:00PM ET/2:00PM PT
- Venue: Ocean Center
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Conclusion
We predict Illinois-Chicago, with an 81% win probability, will likely beat Southern Indiana on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Southern Indiana vs. Illinois-Chicago insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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