Southern Indiana vs. Butler prediction: Butler favored to win men's college basketball matchup [11/5/2025]

Butler will take on Southern Indiana in men's college basketball action at Hinkle Fieldhouse on Wednesday, beginning at 7:00PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Butler as the most likely winner of the Southern Indiana vs. Butler game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Indiana vs. Butler prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball game between Southern Indiana and Butler 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Butler a 96% chance of beating Southern Indiana. Our predicted final score has Butler winning 89-68.

According to our model, Southern Indiana (+22.5) has a 51% chance of covering the spread, while the 156.5-point over/under has a 52% chance of going over.

Southern Indiana vs. Butler odds

We have sourced the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Indiana vs. Butler picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Over 156.5 total points.

Southern Indiana vs. Butler game-day updates and essential details

Wednesday's men's college basketball matchup between Butler and Southern Indiana at Hinkle Fieldhouse is scheduled to begin at 7:00PM ET.

• Who: Southern Indiana vs. Butler
• Date: Wednesday, November 5, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Hinkle Fieldhouse

Conclusion

We predict Butler, with a 96% win probability, will likely beat Southern Indiana on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Southern Indiana vs. Butler insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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