Southern Illinois vs. Memphis prediction: Why Memphis is favored to win men's college basketball matchup [11/26/2025]

Memphis will square off with Southern Illinois in men's college basketball action at FedExForum on Wednesday, beginning at 8:00PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model projects Memphis as the most likely winner of the Southern Illinois vs. Memphis game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Illinois vs. Memphis prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between Southern Illinois and Memphis 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Memphis an 85% chance of beating Southern Illinois. Our predicted final score has Memphis winning 84-72.

According to our model, Memphis (-10.5) has a 54% chance of covering the spread, while the 159.5-point over/under has a 52% chance of staying under.

Southern Illinois vs. Memphis odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Illinois vs. Memphis picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Memphis -10.5 at the spread.

Southern Illinois vs. Memphis game-day updates and essential details

Wednesday's men's college basketball game between Memphis and Southern Illinois at FedExForum is scheduled to commence at 8:00PM ET.

• Who: Southern Illinois vs. Memphis
• Date: Wednesday, November 26, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: FedExForum

Conclusion

We predict Memphis, with an 85% win probability, will likely beat Southern Illinois on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Memphis insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.