Southern Illinois vs. Illinois State prediction: Why Illinois State is favored to win men's college basketball matchup [2/3/2026]

Illinois State will square off with Southern Illinois in men's college basketball action at CEFCU Arena on Tuesday, starting at 7:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Illinois State as the most likely winner of the Southern Illinois vs. Illinois State game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Illinois vs. Illinois State prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the outcome of Tuesday's NCAA basketball matchup between Southern Illinois and Illinois State 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Illinois State an 81% chance of beating Southern Illinois. Our predicted final score has Illinois State winning 75-66.

According to our model, Illinois State (-8.5) has a 52% chance of covering the spread, while the 141.5-point over/under has an equal 50-50 chance of hitting.

Southern Illinois vs. Illinois State odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Illinois vs. Illinois State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: