Southern Illinois vs. Drake prediction: Southern Illinois favored to win men's college basketball matchup [2/18/2026]

Drake will square off with Southern Illinois in men's college basketball action at Knapp Center on Wednesday, commencing at 7:30 PM ET.

Based on the latest simulations, Dimers' proven college basketball model projects Southern Illinois as the most likely winner of the Southern Illinois vs. Drake game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Illinois vs. Drake prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between Southern Illinois and Drake 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Southern Illinois a 57% chance of defeating Drake. Our predicted final score has Southern Illinois winning 75-73.

According to our model, Southern Illinois (-1.5) has a 51% chance of covering the spread, while the over/under total of 149.5 points has a 52% chance of staying under.

Southern Illinois vs. Drake odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Illinois vs. Drake picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: