Southern Illinois vs. Bradley prediction: Bradley favored to win men's college basketball matchup [12/21/2025]

Bradley and Southern Illinois are scheduled to meet in men's college basketball action at Carver Arena on Sunday, with tipoff at 2:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Bradley as the most likely winner of the Southern Illinois vs. Bradley game.

This article offers a closer look at Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Illinois vs. Bradley prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Sunday's NCAA basketball matchup between Southern Illinois and Bradley 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Bradley a 78% chance of beating Southern Illinois. Our predicted final score has Bradley winning 77-69.

According to our model, Bradley (-6.5) has a 57% chance of covering the spread, while the 148.5-point over/under has a 53% chance of staying under.

Southern Illinois vs. Bradley odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Illinois vs. Bradley picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: