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Southern Illinois vs. Bradley prediction: Bradley favored to win men's college basketball matchup [12/21/2025]

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Written by Jason Bevilacqua

Get Southern Illinois vs Bradley predictions for college basketball Sunday.

Southern Illinois-Bradley Predictions and Game Preview.
Southern Illinois vs. Bradley men's college basketball prediction for Sunday, December 21, 2025.

Bradley will face Southern Illinois in men's college basketball action at Carver Arena on Sunday, starting at 2:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Bradley as the most likely winner of the Southern Illinois vs. Bradley game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Illinois vs. Bradley prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of Sunday's NCAA basketball matchup between Southern Illinois and Bradley 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Bradley a 78% chance of beating Southern Illinois. Our predicted final score has Bradley winning 79-70.

According to our model, Bradley (-6.5) has a 57% chance of covering the spread, while the 151.5-point over/under has a 53% chance of staying under.

 

Southern Illinois vs. Bradley odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type Southern Illinois Bradley
Spread +6.5 (-110) -6.5 (-105)
Moneyline +245 -270
Total o151.5 (-110) u151.5 (-110)

All odds are correct at the time of publication and are subject to change.

Southern Illinois vs. Bradley picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Bradley -6.5 -105
Moneyline Bradley -270
Total Under 151.5 -110

According to our men's college basketball best bets, the top play to make on this game is Bradley -6.5 at the spread.

 

Southern Illinois vs. Bradley game-day updates and essential details

Sunday's men's college basketball matchup between Bradley and Southern Illinois at Carver Arena is scheduled to begin at 2:00 PM ET.

  • Who: Southern Illinois vs. Bradley
  • Date: Sunday, December 21, 2025
  • Time: 2:00 PM ET/11:00AM PT
  • Venue: Carver Arena

Conclusion

We predict Bradley, with a 78% win probability, will likely beat Southern Illinois on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Southern Illinois vs. Bradley insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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