South Dakota vs. Creighton prediction: Why Creighton is favored to win men's college basketball matchup [11/5/2025]

Men's college basketball action continues on Wednesday at 8:00PM ET as South Dakota takes on the favored Creighton in men's college basketball action at CHI Health Center Omaha.

Based on the latest simulations, Dimers' advanced college basketball model predicts Creighton as the most likely winner of the South Dakota vs. Creighton game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

South Dakota vs. Creighton prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball matchup between South Dakota and Creighton 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Creighton a 98% chance of defeating South Dakota. Our predicted final score has Creighton winning 94-66.

According to our model, South Dakota (+29.5) has a 53% chance of covering the spread, while the 170.5-point over/under has a 56% chance of staying under.

South Dakota vs. Creighton odds

We have sourced the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

South Dakota vs. Creighton picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Under 170.5 total points.

South Dakota vs. Creighton game-day updates and essential details

Wednesday's men's college basketball matchup between Creighton and South Dakota at CHI Health Center Omaha is scheduled to begin at 8:00PM ET.

• Who: South Dakota vs. Creighton
• Date: Wednesday, November 5, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: CHI Health Center Omaha

Conclusion

We predict Creighton, with a 98% win probability, will likely beat South Dakota on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate South Dakota vs. Creighton insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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