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South Carolina vs. Louisville prediction: South Carolina favored to win women's college basketball matchup [12/4/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get South Carolina vs Louisville predictions for college basketball Thursday.
Louisville will take on the favored South Carolina in women's college basketball action at KFC Yum! Center on Thursday, starting at 7:00PM ET.
Based on updated simulation results, Dimers' new women's basketball model predicts South Carolina as the most likely winner of the South Carolina vs. Louisville game.
This article offers a closer look at Thursday's matchup, including best bets and picks.
South Carolina vs. Louisville prediction: Who will win?
Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's women's basketball matchup between South Carolina and Louisville 10,000 times as part of our women's college basketball predictions coverage.
Our famous predictive model gives South Carolina a 94% chance of beating Louisville.
According to our model, the 139.5-point over/under has a 54% chance of staying under.
South Carolina vs. Louisville odds
We have researched the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | South Carolina | Louisville |
|---|---|---|
| Spread | -14.5 (-110) | +14.5 (-110) |
| Moneyline | -1351 | +1120 |
| Total | o139.5 (-110) | u139.5 (-110) |
All odds are correct at the time of publication and are subject to change.
South Carolina vs. Louisville picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Carolina -14.5 | -110 |
| Moneyline | South Carolina | -1351 |
| Total | Under 139.5 | -110 |
According to our best women's college basketball bets, the top play to make on this game is Under 139.5 total points.
South Carolina vs. Louisville game-day updates and essential details
Thursday's women's basketball action between Louisville and South Carolina at KFC Yum! Center is scheduled to start at 7:00PM ET.
- Who: South Carolina vs. Louisville
- Date: Thursday, December 4, 2025
- Time: 7:00PM ET/4:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict South Carolina, with a 94% win probability, will likely beat Louisville on Thursday.
AI and automation have enhanced this article to quickly deliver accurate South Carolina vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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