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South Carolina vs. Clemson prediction: Why Clemson is favored to win men's college basketball matchup [12/16/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get South Carolina vs Clemson predictions for college basketball Tuesday.
Men's college basketball action continues on Tuesday at 7:00 PM ET as South Carolina squares off with Clemson in men's college basketball action at Littlejohn Coliseum.
Based on the latest simulation results, Dimers' proven college basketball model projects Clemson as the most likely winner of the South Carolina vs. Clemson game.
This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
South Carolina vs. Clemson prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Tuesday's NCAA basketball matchup between South Carolina and Clemson 10,000 times as part of our men's college basketball predictions coverage.
Our independent predictive model currently gives Clemson an 89% chance of defeating South Carolina. Our predicted final score has Clemson winning 79-66.
According to our model, Clemson (-12.5) has a 51% chance of covering the spread, while the 142.5-point over/under has a 54% chance of going over.
South Carolina vs. Clemson odds
We have sourced the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | South Carolina | Clemson |
|---|---|---|
| Spread | +12.5 (-106) | -12.5 (-110) |
| Moneyline | +720 | -1000 |
| Total | o142.5 (-105) | u142.5 (-115) |
All odds are correct at the time of publication and are subject to change.
South Carolina vs. Clemson picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Clemson -12.5 | -110 |
| Moneyline | South Carolina | +720 |
| Total | Over 142.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Over 142.5 total points.
South Carolina vs. Clemson game-day updates and essential details
Tuesday's men's college basketball game between Clemson and South Carolina at Littlejohn Coliseum is scheduled to begin at 7:00 PM ET.
- Who: South Carolina vs. Clemson
- Date: Tuesday, December 16, 2025
- Time: 7:00 PM ET/4:00PM PT
- Venue: Littlejohn Coliseum
Conclusion
We predict Clemson, with an 89% win probability, will likely beat South Carolina on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate South Carolina vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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