South Carolina vs. Clemson prediction: Why Clemson is favored to win men's college basketball matchup [12/16/2025]

Clemson and South Carolina are scheduled to meet in men's college basketball action at Littlejohn Coliseum on Tuesday, with tipoff at 7:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Clemson as the most likely winner of the South Carolina vs. Clemson game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

South Carolina vs. Clemson prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Tuesday's NCAA basketball matchup between South Carolina and Clemson 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Clemson an 87% chance of defeating South Carolina. Our predicted final score has Clemson winning 78-66.

According to our model, the bookmakers have got it right, and South Carolina and Clemson each have a 50% chance of covering the spread, while the 140.5-point over/under has a 56% chance of going over.

South Carolina vs. Clemson odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

South Carolina vs. Clemson picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: