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South Carolina vs. Butler prediction: Butler favored to win men's college basketball matchup [11/21/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get South Carolina vs Butler predictions for college basketball Friday.
Butler will face South Carolina in men's college basketball action at Colonial Hall on Friday, starting at 2:00PM ET.
Based on the latest simulations, Dimers' advanced college basketball model predicts Butler as the most likely winner of the South Carolina vs. Butler game.
This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.
South Carolina vs. Butler prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the result of Friday's NCAA basketball matchup between South Carolina and Butler 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Butler a 62% chance of beating South Carolina. Our predicted final score has Butler winning 78-75.
According to our model, South Carolina (+3.5) has a 51% chance of covering the spread, while the over/under total of 150.5 points has a 54% chance of going over.
South Carolina vs. Butler odds
We have sourced the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | South Carolina | Butler |
|---|---|---|
| Spread | +3.5 (-105) | -3.5 (-110) |
| Moneyline | +155 | -180 |
| Total | o150.5 (-115) | u150.5 (-105) |
All odds are correct at the time of publication and are subject to change.
South Carolina vs. Butler picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Carolina +3.5 | -105 |
| Moneyline | South Carolina | +155 |
| Total | Over 150.5 | -115 |
According to our best men's college basketball bets, the top play to make on this game is Over 150.5 total points.
South Carolina vs. Butler game-day updates and essential details
Friday's men's college basketball action between Butler and South Carolina at Colonial Hall is scheduled to start at 2:00PM ET.
- Who: South Carolina vs. Butler
- Date: Friday, November 21, 2025
- Time: 2:00PM ET/11:00AM PT
- Venue: Colonial Hall
Conclusion
We predict Butler, with a 62% win probability, will likely beat South Carolina on Friday.
AI and automation have enhanced this article to quickly deliver accurate South Carolina vs. Butler insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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