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South Carolina State vs. Louisville prediction: Louisville favored to win men's college basketball matchup [11/3/2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get South Carolina State vs Louisville predictions for college basketball Monday.
Louisville will take on South Carolina State in men's college basketball opening night action at KFC Yum! Center on Monday, starting at 9:00PM ET.
Based on updated simulations, Dimers' advanced college basketball model predicts the Louisville as the most likely winner of the South Carolina State vs. Louisville game.
This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.
South Carolina State vs. Louisville prediction: Who will win, cover the spread?
Using powerful machine learning and data, we have simulated the outcome of Monday's NCAA basketball game between South Carolina State and Louisville 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Louisville a 99% chance of beating South Carolina State. Our predicted final score has Louisville winning 93-63.
According to our model, South Carolina State (+36.5) has a 58% chance of covering the spread, while the 158.5-point over/under has a 53% chance of staying under.
South Carolina State vs. Louisville odds
We have researched the best college basketball odds in America for this game, which are listed here:
| Bet Type | South Carolina State | Louisville |
|---|---|---|
| Spread | +36.5 (-105) | -36.5 (-112) |
| Moneyline | +8000 | -100000 |
| Total | o158.5 (-105) | u158.5 (-115) |
All odds are correct at the time of publication and are subject to change.
South Carolina State vs. Louisville picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Carolina State +36.5 | -105 |
| Moneyline | South Carolina State | +8000 |
| Total | Under 158.5 | -115 |
According to our men's college basketball best bets, the top play to make on this game is South Carolina State +36.5 at the spread.
South Carolina State vs. Louisville game-day updates and essential details
Monday's men's college basketball action between Louisville and South Carolina State at KFC Yum! Center is scheduled to start at 9:00PM ET.
- Who: South Carolina State vs. Louisville
- Date: Monday, November 3, 2025
- Time: 9:00PM ET/6:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Louisville, with a 99% win probability, will likely beat South Carolina State on Monday.
AI and automation have enhanced this article to quickly deliver accurate South Carolina State vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on men's college basketball
Keep up with the latest men's college basketball betting news and CBB parlay picks throughout the season. Plus, our NCAA Tournament Championship odds offer the most up-to-date probabilities for every March Madness contender.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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