SMU vs. Clemson prediction: Why Clemson is favored to win men's college basketball matchup [1/7/2026]

Clemson will face SMU in men's college basketball action at Littlejohn Coliseum on Wednesday, commencing at 9:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Clemson as the most likely winner of the SMU vs. Clemson game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

SMU vs. Clemson prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball matchup between SMU and Clemson 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Clemson a 64% chance of beating SMU. Our predicted final score has Clemson winning 76-72.

According to our model, SMU (+3.5) has a 51% chance of covering the spread, while the over/under total of 149.5 points has a 54% chance of going over.

SMU vs. Clemson odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

SMU vs. Clemson picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: