SIUE vs. Western Illinois prediction: Why SIU-Edwardsville is favored to win men's college basketball matchup [12/22/2025]

Western Illinois and SIUE are scheduled to meet in men's college basketball action at LeRoy A. Ufkes Court at Western Hall on Monday, with tipoff at 4:30 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts SIU-Edwardsville as the most likely winner of the SIUE vs. Western Illinois game.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and picks.

SIUE vs. Western Illinois prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Monday's NCAA basketball matchup between SIUE and Western Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives SIU-Edwardsville a 71% chance of defeating Western Illinois. Our predicted final score has SIU-Edwardsville winning 69-64.

According to our model, Western Illinois (+5.5) has a 51% chance of covering the spread, while the over/under total of 131.5 points has a 53% chance of going over.

SIUE vs. Western Illinois odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

SIUE vs. Western Illinois picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: