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Read Article Mariners vs. Padres Prediction: San Diego Predicted to Win Saturday's MLB Matchup [5/17/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Our expert prediction for Saturday's Seattle Mariners vs San Diego Padres matchup.
The San Diego Padres will take on the Seattle Mariners in MLB action at PETCO Park on Saturday, commencing at 8:40PM ET.
Nick Pivetta (5-2, 3.04 ERA) will be the starting pitcher for the Padres, while the Mariners have opted for Emerson Hancock (1-2, 6.91 ERA).
Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.
"Our team has used the latest data to run 10,000 simulations of Saturday's Seattle-San Diego game," said Dimers' Chief Content Officer, Nick Slade.
"By incorporating recent updates and various other inputs, we estimate that the Padres are more likely to win, while the Mariners have a lower chance of victory."
For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Mariners vs. Padres predictions page.
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Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's MLB matchup between the Mariners and Padres 10,000 times as part of our MLB predictions coverage.
Our leading predictive model gives the Padres a 64% chance of defeating the Mariners.
According to our model, the Mariners (+1.5) have a 54% chance of covering the run line, while the over/under total of 8 runs has a 55% chance of going over.
Pre-Game Probabilities
Last Updated: 12:27AM, May 18
Moneyline
Over / Under
Run Line
Emerson Hancock 1-2, 6.91 ERA
Nick Pivetta 5-2, 3.05 ERA
Get the best bets with Dimers Pro
Mariners vs. Padres Odds [5/17/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Mariners | Padres |
|---|---|---|
| Run Line | +1.5 (-122) | -1.5 (+110) |
| Moneyline | +164 | -190 |
| Total | o8 (-120) | u8 (-102) |
All odds are correct at the time of publication and are subject to change.
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Mariners vs. Padres Picks and Best Bets
Our model's strongest edge in today's Mariners vs. Padres matchup is on the run line.
Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
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Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.
Mariners vs. Padres Game-Day Updates and Essential Details
Saturday's MLB matchup between the Padres and Mariners at PETCO Park is scheduled to start at 8:40PM ET.
- Who: Seattle Mariners vs. San Diego Padres
- Date: Saturday, May 17, 2025
- Time: 8:40PM ET/5:40PM PT
- Venue: PETCO Park
Dimers.com's full preview of Saturday's Mariners vs. Padres matchup includes our prediction, picks and the latest betting odds.
Before making any Seattle vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Padres, with a 64% win probability, will likely beat the Mariners on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Mariners vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the latest projections for the World Series, American League, National League and each division.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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