Mariners vs. White Sox Prediction: Seattle Predicted to Win Wednesday's MLB Matchup [5/21/2025]

MLB action continues on Wednesday at 2:10PM ET as the Seattle Mariners take on the Chicago White Sox at Rate Field.

The White Sox will start Shane Smith (1-3, 2.05 ERA), while the Mariners have opted for Logan Evans (2-1, 2.57 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Mariners as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Seattle-CHI White Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Mariners' chance of winning at 56%, with the White Sox at 44%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Mariners vs. White Sox predictions page.

White Sox vs. Mariners Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Mariners and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Mariners a 56% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 58% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Mariners vs. White Sox Odds [5/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Mariners	White Sox
Run Line	-1.5 (+110)	+1.5 (-126)
Moneyline	-148	+130
Total	o8.5 (-108)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Mariners vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Mariners vs. White Sox matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Mariners vs. White Sox Game-Day Updates and Essential Details

Wednesday's MLB matchup between the White Sox and Mariners at Rate Field is scheduled to begin at 2:10PM ET.

• Who: Seattle Mariners vs. Chicago White Sox
• Date: Wednesday, May 21, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Rate Field

Dimers.com's full preview of Wednesday's Mariners vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Seattle vs. CHI White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Mariners, with a 56% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mariners vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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