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49ers vs. Buccaneers prediction: Why Tampa Bay is favored to win in NFL Week 6, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get San Francisco 49ers vs Tampa Bay Buccaneers predictions for NFL Sunday.
The Tampa Bay Buccaneers will take on the San Francisco 49ers in NFL Week 6 action at Raymond James Stadium on Sunday, commencing at 4:25PM ET.
Based on updated simulations, Dimers' proven NFL model predicts the Buccaneers as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's 49ers-Buccaneers game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Buccaneers with a win probability of 61%, while the 49ers have 39%."
This gameday 49ers vs. Buccaneers betting preview builds on my 49ers vs. Buccaneers prediction that was released earlier in the week.
For a closer look at today’s game, including the predicted score, best bets and player prop picks, visit our interactive 49ers vs. Buccaneers predictions page.
49ers vs. Buccaneers predictions
Since our 49ers-Buccaneers predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the 49ers and Buccaneers 10,000 times as part of our NFL predictions coverage.
Our famous predictive model gives the Buccaneers a 61% chance of beating the 49ers in Week 6 of the NFL season. Our predicted final score has the Buccaneers winning 24-21.
According to our model, the bookmakers have got it right, and the 49ers and Buccaneers each have a 50% chance of covering the spread, while the over/under total of 46.5 points also has an equal 50-50 chance of hitting.
To see win probabilities for every matchup this week, check out our expert NFL Week 6 straight up picks.
49ers vs. Buccaneers odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | 49ers | Buccaneers |
|---|---|---|
| Spread | +3.5 (-105) | -3.5 (-105) |
| Moneyline | +166 | -185 |
| Total | o46.5 (-118) | u46.5 (+100) |
All odds are correct at the time of publication and are subject to change.
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49ers vs. Buccaneers picks and best bets
Our model's strongest edge in today's 49ers vs. Buccaneers matchup is on the moneyline.
Our expert predictions, aligned with the best odds, reveal the best NFL picks and NFL best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
49ers vs. Buccaneers TD scorers
Who will score the first touchdown in 49ers vs. Buccaneers?
According to our list of touchdown scorer predictions for Week 6, San Francisco's Christian McCaffrey is most likely to score the first touchdown in 49ers vs. Buccaneers.
Our projections give McCaffrey a 14.1% chance of getting in for six first at Raymond James Stadium, while the 49ers running back is a 56.2% chance of reaching the end zone at any point in the game.
First touchdown scorer predictions
San Francisco 49ers
| Player | First TD Probability |
|---|---|
| Christian McCaffrey (RB) | 14.1% |
| Jauan Jennings (WR) | 6.2% |
| Kendrick Bourne (WR) | 5.1% |
Tampa Bay Buccaneers
| Player | First TD Probability |
|---|---|
| Rachaad White (RB) | 14.0% |
| Emeka Egbuka (WR) | 11.4% |
| Cade Otton (TE) | 5.2% |
Anytime touchdown scorer predictions
San Francisco 49ers
| Player | Anytime TD Probability |
|---|---|
| Christian McCaffrey (RB) | 56.2% |
| Jauan Jennings (WR) | 30.2% |
| Kendrick Bourne (WR) | 25.7% |
Tampa Bay Buccaneers
| Player | Anytime TD Probability |
|---|---|
| Rachaad White (RB) | 53.3% |
| Emeka Egbuka (WR) | 46.2% |
| Cade Otton (TE) | 24.6% |
49ers vs Buccaneers player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Buccaneers. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our NFL player projections page now to access player prop projections for every offensive player in this matchup and all other Week 6 games.
49ers vs. Buccaneers quarterbacks
Of the starting quarterbacks, the 49ers' Mac Jones is projected to throw for fewer yards than the Buccaneers' Baker Mayfield.
49ers rushing
Christian McCaffrey, Brian Robinson and Mac Jones are projected to be the leading rushers for the 49ers.
| Player | Position |
|---|---|
| Christian McCaffrey | RB |
| Brian Robinson | RB |
| Mac Jones | QB |
Buccaneers rushing
Rachaad White, Baker Mayfield and Sean Tucker are expected to lead the Buccaneers in rushing yards.
| Player | Position |
|---|---|
| Rachaad White | RB |
| Baker Mayfield | QB |
| Sean Tucker | RB |
49ers receiving
Jauan Jennings, Christian McCaffrey, Kendrick Bourne, Jake Tonges and Demarcus Robinson are projected to top the receiving yards for the 49ers.
| Player | Position |
|---|---|
| Jauan Jennings | WR |
| Christian McCaffrey | RB |
| Kendrick Bourne | WR |
| Jake Tonges | TE |
| Demarcus Robinson | WR |
Buccaneers receiving
Emeka Egbuka, Sterling Shepard, Tez Johnson, Cade Otton and Rachaad White are projected to lead the Buccaneers in receiving yards.
| Player | Position |
|---|---|
| Emeka Egbuka | WR |
| Sterling Shepard | WR |
| Tez Johnson | WR |
| Cade Otton | TE |
| Rachaad White | RB |
Niners vs. Bucs game-day updates and essential details
The NFL Week 6 action between the Buccaneers and 49ers at Raymond James Stadium is scheduled to commence at 4:25PM ET.
- Who: San Francisco 49ers vs. Tampa Bay Buccaneers
- Date: Sunday, October 12, 2025
- Time: 4:25PM ET/1:25PM PT
- Venue: Raymond James Stadium
Dimers' in-depth preview of Sunday's 49ers vs. Buccaneers matchup includes our prediction, picks and the latest betting odds.
Before making any Niners vs. Bucs picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
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Conclusion
We predict the Buccaneers, with a 61% win probability, will likely beat the 49ers in Week 6 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Buccaneers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on NFL
Stay informed with the latest NFL news and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the latest probabilities for the Super Bowl, AFC, NFC and each division.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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