San Francisco 49ers vs. Tampa Bay Buccaneers updated prediction featuring Christian McCaffrey, Rachaad White [Week 6, 2025]

Dimers' latest NFL predictions are live for Tampa Bay Buccaneers and San Francisco 49ers in Week 6, with our model giving the Buccaneers a 59% of winning against the 49ers on Sunday.

This update builds on our early Buccaneers-49ers predictions, adding renewed win probabilities, score projections, and TD predictions for Christian McCaffrey, Rachaad White, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our 49ers vs. Buccaneers page.

What's changed? San Francisco vs. Tampa Bay updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Niners vs. Bucs matchup stacks up. Here are the updated forecasted:

• Straight Up Win Probabilities: 49ers 41%, Buccaneers 59%
• Predicted Final Score: 49ers 22-24 Buccaneers
• Spread: 49ers (+3) 50%, Buccaneers (-3) 50%
• Total Points (47.5): Over 46%, Under 54%

As of October 9, 2025, these 49ers-Buccaneers numbers reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 6 highlight the top candidates to find the end zone in Niners-Bucs on Sunday:

San Francisco 49ers

• Christian McCaffrey: 56.8% probability
• Jauan Jennings: 28.1% probability
• Ricky Pearsall: 25.8% probability

Tampa Bay Buccaneers

• Rachaad White: 55.6% probability
• Emeka Egbuka: 43.2% probability
• Chris Godwin: 28.3% probability

Niners vs. Bucs latest odds

The best current odds from the top sportsbooks in the US:

• Spread: 49ers +3 (-105), Buccaneers -3 (-105)
• Moneyline: 49ers +140, Buccaneers -154
• Total: Over/Under 47.5 (-108/-110)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Niners vs. Bucs Week 6 details

The NFL Week 6 action between the Buccaneers and 49ers at Raymond James Stadium is scheduled for October 12, 2025.

• Who: San Francisco 49ers vs. Tampa Bay Buccaneers
• Date: Sunday, October 12, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Raymond James Stadium

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Conclusion

We predict the Buccaneers, with a 59% win probability, will likely beat the 49ers in Week 6 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Buccaneers matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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