San Francisco 49ers vs. Arizona Cardinals updated prediction featuring Christian McCaffrey, Trey McBride [Week 11, 2025]

Dimers' latest NFL predictions are live for Arizona Cardinals vs. San Francisco 49ers in Week 11, with our model giving the 49ers a 59% of winning on Sunday.

In the days leading up to kickoff, both teams have made changes to their official injury reports, as practice participation and player availability continue to evolve heading into the weekend. These updates could influence how each side approaches key matchups in this NFC West matchup.

Building on those developments, we have fresh updates since our early Cardinals-49ers predictions, delivering recalculated win probabilities, score projections, and TD predictions for Christian McCaffrey, Trey McBride, and more.

For the most accurate simulation-based insights—including spread and total picks, touchdown probabilities, and the full list of player props—head to our 49ers vs. Cardinals page.

What's changed? San Francisco vs. Arizona updated predictions

Our NFL predictions model has been re-run with the newest available data, creating a clearer picture of how this Niners vs. Cardinals matchup stacks up. Here are the updated forecasts:

• Straight Up Win Probabilities: 49ers 59%, Cardinals 41%
• Predicted Final Score: 49ers 24-22 Cardinals
• Spread: 49ers (-3) 44%, Cardinals (+3) 56%
• Total Points (48.5): Over 47%, Under 53%

As of November 13, 2025, these 49ers-Cardinals numbers reflect changes since our early-week simulation.

Anytime touchdown scorer predictions

New NFL player projections for Week 11 highlight the top candidates to find the end zone in Niners-Cardinals on Sunday:

San Francisco 49ers

• Christian McCaffrey: 65.1% probability
• George Kittle: 40.0% probability
• Jauan Jennings: 31.9% probability

Arizona Cardinals

• Trey McBride: 40.2% probability
• Emari Demercado: 33.2% probability
• Trey Benson: 28.0% probability

Niners vs. Cardinals latest odds

The best current odds from the top sportsbooks in the US:

• Spread: 49ers -3 (-105), Cardinals +3 (-110)
• Moneyline: 49ers -155, Cardinals +138
• Total: Over/Under 48.5 (-108/-112)

Odds are correct at time of publication and are subject to change—track live updates via our NFL odds page.

Niners vs. Cardinals Week 11 details

The NFL Week 11 game between the Cardinals and 49ers at State Farm Stadium is scheduled for November 16, 2025.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Sunday, November 16, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Cardinals in Week 11 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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