San Francisco 49ers vs. Arizona Cardinals: Experts release early Week 11 predictions [2025]

The San Francisco 49ers and Arizona Cardinals will meet in Week 11 of the NFL season at State Farm Stadium on Sunday, November 16, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the 49ers as the most likely winner of this NFC West rivalry matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive 49ers vs. Cardinals predictions page.

San Francisco vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Niners vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: 49ers 61%, Cardinals 39%
• Predicted final score: 49ers 25-22 Cardinals
• Spread: 49ers (-2.5) 56%, Cardinals (+2.5) 44%
• Total points (49): Over 44%, Under 56%

As of November 10, 2025, these 49ers-Cardinals figures and predictions reflect the latest data and insights available.

Niners vs. Cardinals Week 11 details

The NFL Week 11 action between the Cardinals and 49ers at State Farm Stadium is scheduled for November 16, 2025.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Sunday, November 16, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

Niners vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 11 game, which are listed here:

• Spread: 49ers -2.5 (-115), Cardinals +2.5 (-105)
• Moneyline: 49ers -148, Cardinals +132
• Total: Over/Under 49 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

Anytime touchdown scorer predictions

Early NFL player projections for Week 11 highlight the top candidates to score a TD in Niners-Cardinals in Week 11:

San Francisco 49ers

• Christian McCaffrey: 61.3% probability
• George Kittle: 33.6% probability
• Jauan Jennings: 27.7% probability

Arizona Cardinals

• Emari Demercado: 35.1% probability
• Marvin Harrison: 32.6% probability
• Trey McBride: 32.5% probability

49ers vs Cardinals player props

Christian McCaffrey is projected to lead rushing for the 49ers, while Emari Demercado is expected to pace the Cardinals on the ground.

In the receiving game, our projections favor San Francisco's Jauan Jennings and Arizona's Trey McBride as the likely leaders for each team.

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Conclusion

We predict the 49ers, with a 61% win probability, will likely beat the Cardinals in Week 11 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the 49ers vs. Cardinals game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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