49ers vs. Cardinals prediction: Why San Francisco is favored to win in NFL Week 11, 2025

The Arizona Cardinals will take on the San Francisco 49ers in NFL Week 11 action at State Farm Stadium on Sunday, beginning at 4:05PM ET.

Based on the latest simulations, Dimers' proven NFL model projects the 49ers as the most likely winner of the 49ers vs. Cardinals game.

This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Niners vs. Cardinals prediction: Who will win and cover?

Since our 49ers-Cardinals predictions earlier in the week, we have simulated the result of Sunday's NFL game between the 49ers and Cardinals 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the 49ers a 60% chance of beating the Cardinals in Week 11 of the NFL season. Our predicted final score has the 49ers winning 25-22.

According to our model, the Cardinals (+3.5) have a 59% chance of covering the spread, while the over/under total of 48.5 points has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 11 straight up picks.

49ers vs. Cardinals odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	49ers	Cardinals
Spread	-3.5 (+100)	+3.5 (-105)
Moneyline	-185	+160
Total	o48.5 (-108)	u48.5 (-106)

All odds are correct at the time of publication and are subject to change.

49ers vs. Cardinals picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Cardinals +3.5	-105
Moneyline	Cardinals	+160
Total	Under 48.5	-106

According to our NFL best bets, the top play to make on this game is Cardinals +3.5 at the spread.

49ers vs. Cardinals TD scorers

Who will score a touchdown in 49ers vs. Cardinals?

According to our list of touchdown scorer predictions for today, Christian McCaffrey is most likely to score an anytime TD in 49ers vs. Cardinals.

Our projections give McCaffrey a 63.8% chance of scoring a TD at State Farm Stadium, while the running back is a 17.5% chance of registering the first touchdown the game.

Anytime touchdown scorer predictions

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	63.8%
George Kittle (TE)	37.1%
Jauan Jennings (WR)	29.4%
Ricky Pearsall (WR)	26.9%
Brian Robinson (RB)	16.7%

Arizona Cardinals

Player	Anytime TD Probability
Trey McBride (TE)	43.9%
Bam Knight (RB)	38.8%
Emari Demercado (RB)	27.0%
Michael Wilson (WR)	26.7%
Greg Dortch (WR)	23.5%

First touchdown scorer predictions

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	17.5%
George Kittle (TE)	8.0%
Jauan Jennings (WR)	6.0%
Ricky Pearsall (WR)	5.4%
Brian Robinson (RB)	3.1%

Arizona Cardinals

Player	First TD Probability
Trey McBride (TE)	10.0%
Bam Knight (RB)	8.5%
Emari Demercado (RB)	5.5%
Michael Wilson (WR)	5.4%
Greg Dortch (WR)	4.6%

49ers vs Cardinals player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the 49ers and Cardinals. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 11 games.

Quarterbacks

Of the starting quarterbacks, the 49ers' Brock Purdy is projected for 256 passing yards. The Cardinals' Jacoby Brissett is expected to throw for 233 yards.

Player	Proj. Pass Yards
Brock Purdy (SF)	256
Jacoby Brissett (ARI)	233

49ers rushing

Player	Proj. Rush Yards
Christian McCaffrey	75
Brian Robinson	24
Brock Purdy	13

Cardinals rushing

Player	Proj. Rush Yards
Bam Knight	44
Emari Demercado	41
Jacoby Brissett	20

49ers receiving

Player	Proj. Rec. Yards
Jauan Jennings	54
George Kittle	54
Christian McCaffrey	50
Ricky Pearsall	46
Kendrick Bourne	16

Cardinals receiving

Player	Proj. Rec. Yards
Trey McBride	74
Michael Wilson	51
Greg Dortch	34
Elijah Higgins	16
Xavier Weaver	12

Niners vs. Cardinals game-day updates and essential details

The NFL Week 11 game between the Cardinals and 49ers at State Farm Stadium is scheduled to commence at 4:05PM ET.

• Who: San Francisco 49ers vs. Arizona Cardinals
• Date: Sunday, November 16, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: State Farm Stadium

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Conclusion

We predict the 49ers, with a 60% win probability, will likely beat the Cardinals in Week 11 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate 49ers vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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