San Diego State vs. Grand Canyon prediction: Grand Canyon favored to win men's college basketball matchup [1/21/2026]

Grand Canyon will face San Diego State in men's college basketball action at Global Credit Union Arena on Wednesday, commencing at 11:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Grand Canyon as the most likely winner of the San Diego State vs. Grand Canyon game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

San Diego State vs. Grand Canyon prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between San Diego State and Grand Canyon 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Grand Canyon a 55% chance of beating San Diego State. Our predicted final score has Grand Canyon winning 75-73.

According to our model, Grand Canyon (+1.5) has a 56% chance of covering the spread, while the 145.5-point over/under has a 55% chance of going over.

San Diego State vs. Grand Canyon odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

San Diego State vs. Grand Canyon picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Grand Canyon to win.

San Diego State vs. Grand Canyon game-day updates and essential details

Wednesday's men's college basketball action between Grand Canyon and San Diego State at Global Credit Union Arena is scheduled to start at 11:00 PM ET.

• Who: San Diego State vs. Grand Canyon
• Date: Wednesday, January 21, 2026
• Time: 11:00 PM ET/8:00PM PT
• Venue: Global Credit Union Arena

Conclusion

We predict Grand Canyon, with a 55% win probability, will likely beat San Diego State on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate San Diego State vs. Grand Canyon insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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