Padres vs. Yankees Prediction: Yankees Predicted to Win Wednesday's MLB Matchup [5/7/2025]

The New York Yankees will face the San Diego Padres in MLB action at Yankee Stadium on Wednesday, starting at 7:05PM ET.

The Yankees will start Max Fried (6-0, 1.01 ERA), while the Padres have opted for Dylan Cease (1-2, 5.61 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) projects the Yankees as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's San Diego-NY Yankees game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 59%, with the Padres at 41%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Padres vs. Yankees predictions page.

Yankees vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Padres and Yankees 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Yankees a 59% chance of defeating the Padres.

According to our model, the Padres (+1.5) have a 60% chance of covering the run line, while the 8-run over/under has a 54% chance of staying under.

Padres vs. Yankees Odds [5/7/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Padres	Yankees
Run Line	+1.5 (-135)	-1.5 (+122)
Moneyline	+150	-172
Total	o8 (-106)	u8 (-108)

All odds are correct at the time of publication and are subject to change.

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Padres vs. Yankees Picks and Best Bets

Our model's strongest edge in today's Padres vs. Yankees matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Padres vs. Yankees Game-Day Updates and Essential Details

Wednesday's MLB game between the Yankees and Padres at Yankee Stadium is scheduled to begin at 7:05PM ET.

• Who: San Diego Padres vs. New York Yankees
• Date: Wednesday, May 7, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers.com's in-depth preview of Wednesday's Padres vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any San Diego vs. NY Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 59% win probability, will likely beat the Padres on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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