Padres vs. Reds Prediction: San Diego Predicted to Win Friday's MLB Matchup [6/27/2025]

The Cincinnati Reds will face the San Diego Padres in MLB action at Great American Ball Park on Friday, commencing at 7:10PM ET.

The Reds will start Nick Martinez (4-8, 4.40 ERA), up against Dylan Cease (3-6, 4.43 ERA) for the Padres.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Padres-Reds game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Padres' chance of winning is 55%, while the Reds' is 45%."

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Padres vs. Reds predictions page.

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Reds vs. Padres Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Friday's MLB game between the Padres and Reds 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Padres a 55% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 57% chance of covering the run line, while the 9.5-run over/under has a 57% chance of staying under.

Pre-Game Probabilities

Last Updated: 10:33PM, Jun 27

Moneyline

Over / Under

Run Line

Padres

Win %

55%

45%

-130

+112

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Reds

Padres SD

-130

Win %

55%

45%

See Matchup

Reds CIN

+112

Dylan Cease 3-6, 4.43 ERA

Nick Martinez 4-8, 4.40 ERA

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Padres vs. Reds Odds [6/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Padres vs. Reds Picks and Best Bets

Our model's biggest edge in today's Padres vs. Reds matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free MLB Picks

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Padres vs. Reds Game-Day Updates and Essential Details

Friday's MLB action between the Reds and Padres at Great American Ball Park is scheduled to start at 7:10PM ET.

• Who: San Diego Padres vs. Cincinnati Reds
• Date: Friday, June 27, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Great American Ball Park

Dimers.com's comprehensive preview of Friday's Padres vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Padres vs. Reds picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Padres, with a 55% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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